Cannot open EMC on exchange server

I am having a strange problem. I have an exchange 2010 server on windows 2008 r2 that has been working perfectly for more than a year. Now suddenly I can't open the EMC or even the EMS.
I get this error,
"The attempt to connect to the server using kerberos failed..............connection to the specified remote host was refused. Verify that the WS-Management service is running on the remote host and configured to listen for requests on the correct
port and HTTP URL"
I have tried everything I can think of, winrm quickconfig and
WinRM enumerate winrm/config/listener both seem to be normal.
in IIS, the "MsexchangePowershellAppPool" application pool is running and under powershell Virtual directory both
kerbauth and WS-Man are native and local.
I don't know what else to do and how to get this EMC (and EMS) to work again.....

Try following
Method 1:
Close all MMC/EMC instances before proceeding.
Open Registry Editor (regedit) as the user you run the EMC under.
Go to
HKEY_CURRENT_USER\SOFTWARE\Microsoft\ExchangeServer\v14\AdminTools
Look for value NodeStructureSetting.
If it is there, back it up and then remove it.
Method 2:
Close all MMC/EMC Instances before proceeding.
Open Powershell or Powershell IDE as the user you run the EMC under and execute the following command:.
Remove-ItemProperty -Path HKCU:\Software\Microsoft\ExchangeServer\v14\AdminTools\ -Name NodeStructureSettings
Close Powershell
After performing either of the methods above to remove the registry entry you should be able to open the Exchange Management Console and it will discover another Exchange server and connect.
Lrok

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HI all-
      I built a new user and gave them the recipient management role. I also made them an admin on one of the servers, but EMC will not open for them. This server is a dedicated VM for the help desk to build new mailboxes. I,
and other users, can open EMC and function normally on this server.
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Thank you for your post.
If the user can open EMC on other server, it means the RBAC permission is fine.
If other user can work on this server, it means the server settings are fine.
What I can think of is to get the RBAC permission and AD permission of a problematic user and a good user have compared with them.
In addition, disabling UAC can also be a good try.
If there are any questions regarding this issue, please be free to let me know.
Best regard,
Jim

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I am stuck. I cannot open the EMC or EMS on either the Exchange 2010 server (all roles are on a single server) or on another server that I have the management tools installed on, both of which are Server 2012 R2. I keep getting Access Denied,
though at times it was Internal Server error (see below).
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EMTshooter - could not determine the problem "Could not connect to any Exchange server in the current site. problem found: looking for error... unknown error"
Verified that kerbauth is registered on the PowerShell virtual directory and only the PowerShell virtual directory (Native/Local)
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Ensured that there is no redirection going on with any virtual directory or the root site
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Tried adding another Domain Admin account to the Org Mgmt group, and connecting as that user but same results
Tried resetting the Administrator profile and clearing all the cache files
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Verified in ApplicationHost.config the entry for WSMan (image="C:\Windows\system32\wsmsvc.dll")
Verified in ApplicationHost.config the entry for kerbauth (image="C:\Program Files\Microsoft\Exchange Server\V14\Bin\kerbauth.dll")
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I would have liked to uninstall and reinstall Windows Management Framework and/or Windows Remote Management, but being Server 2012 R2, that is not an option.
Interestingly enough, users currently have no problems accessing their mailboxes, via Outlook or OWA - it's just we cannot manage the server. Any help on what to try next is greatly appreciated...
-Michael.

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