Data compression can have negative impact on application ?

Hi,
They are going to analyse table/index structure & go ahead with data compression in order to speed up the performance.
We have been asked to verify if data compression will have affect the application or not?
For ex: we run one process which we run through application which rebuild index of a big table. So I may put this thing in effect.
But could please help me which all areas I should focus and investigate before asking them to proceed for data compression?
-Vaibhav Chaudhari

This article will give you most of the answers:
http://technet.microsoft.com/en-us/library/dd894051(v=sql.100).aspx

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