Images cut from Microsoft Word document being picked up in the file size by Acrobat distiller

Hello All;
I have a large MS Word document (book manuscript) with almost 400 images (all grayscale) and found that the tiff images needed to be replaced with jpegs to reduce the file size. I created the jpegs, cut the tiff images from the document, and inserted the replacement jpeg image for each tiff image cut. It reduce the file size in Word from 595 Mb to 210Mb. However, when I ran the distiller, it is somehow picking up the file sizes of the tiff files as it still gives roughly the same output (595 Mb) for the Acrobat document. Is there a way I strip out the tiff image overhead from the pdf or a way I can cleanse it from the MS Word document? Thanks in advance.

Acrobat automatically compresses images when a PDF is made, usually doing something equivalent to JPEG (it's your choice, check the creation options).
So, changing from TIFF to JPEG in the original file will usually make not a bit of difference to the original file size. 
There is no simple 1 to 1 connection between the size of a Word document and a PDF. Some things are bigger, some are smaller.
You can experiment with Save as ... optimized PDF settings. Also, use Audit Space Usage in that dialog to see what is using the space.

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