InDesign CS5 suddenly slower...

Question

In Design CS5 has been running intermittently very slow recently. It will run normally for a while; then in the middle of a simple operation like copying a small piece of text, everything stalls and I get the pinwheel of death for an undetermined amount of time. Never long enought for me to bother force quitting, but happens frequently enough that it's really hindeirng my ability to get work done.
Have done some heavy work on old, imported files from CS3 and CS4 files lately. Also  have recently installed trial versions of Final Cut Pro X and Adobe Production Premium CS5.5, but "completely" uninstalled those using the correct utilites and re-installed CS5 Design Premium afterwards. There have been some Apple Snow Leopard updates recently too. The kind of behavior I see on my activity monitor makes me think it's looking for something on a network somewhere. Either it takes a while and succeeds or it gives up and eventually moves on to the next thing. No other software being effected noticealbly except Illustrator CS5, but I use it less, so hard to name symptoms. All the CS5 apps used to run lickety split fast on this machine and just cleaned out a bunch of fonts. Things were better for a while, but now slower than before. 
I've looked all over and noone else seems to be having this problem. Thoughts anyone?
Here's a random sample from the activity monitor:
Sampling process 496 for 3 seconds with 1 millisecond of run time between samples
Sampling completed, processing symbols...
Analysis of sampling CS5ServiceManager (pid 496) every 1 millisecond
Call graph:
    2467 Thread_8368   DispatchQueue_1: com.apple.main-thread  (serial)
      2467 start
        2467 main
          2467 adobe_csi::ServiceManager::Run()
            2467 vcfoundation::system::IVCRunLoop::RunGUILoop()
              2467 -[NSApplication run]
                2467 -[NSApplication nextEventMatchingMask:untilDate:inMode:dequeue:]
                  2467 _DPSNextEvent
                    2467 BlockUntilNextEventMatchingListInMode
                      2467 ReceiveNextEventCommon
                        2467 RunCurrentEventLoopInMode
                          2467 CFRunLoopRunInMode
                            2467 CFRunLoopRunSpecific
                              2467 __CFRunLoopRun
                                2467 mach_msg
                                  2467 mach_msg_trap
    2467 Thread_8370   DispatchQueue_2: com.apple.libdispatch-manager  (serial)
      2467 start_wqthread
        2467 _pthread_wqthread
          2467 _dispatch_worker_thread2
            2467 _dispatch_queue_invoke
              2467 _dispatch_mgr_invoke
                2466 kevent
                1 _dispatch_run_timers
                  1 _dispatch_wakeup
                    1 _dispatch_queue_push_list_slow
                      1 _dispatch_wakeup
                        1 _dispatch_queue_push_list_slow
                          1 _dispatch_wakeup
                            1 _dispatch_queue_wakeup_global
                              1 pthread_workqueue_additem_np
                                1 pick_nextworkqueue_droplock
                                  1 __workq_kernreturn
    2467 Thread_8373
      2467 thread_start
        2467 _pthread_start
          2467 vcfoundation::thread::Thread::ThreadProc(void*)
            2467 vcfoundation::thread::AbstractThread::Run()
              2467 vcfoundation::ncomm::NCHost::Server::Run()
                2467 vcfoundation::ncomm::NCHost::Server::Accept()
                  2467 vcfoundation::io::BSDPipeServer::Accept()
                    2467 vcfoundation::net::Bsd::Accept(int, sockaddr*, int*)
                      2467 accept$UNIX2003
    2467 Thread_8377
      2467 thread_start
        2467 _pthread_start
          2467 vcfoundation::thread::Thread::ThreadProc(void*)
            2467 vcfoundation::thread::AbstractThread::Run()
              2467 vcfoundation::ncomm::NCHost::Worker::Run()
                2467 vcfoundation::ncomm::NCHost::Worker::HandleRequest()
                  2467 vcfoundation::ncomm::NCHost::ExecuteRequest(vcfoundation::ncomm::INCHost::IRequest*)
                    2467 adobe_csi::AbstractRequest::Execute()
                      2467 adobe_csi::WaitForGlobalCSXSEventRequest::DoExecute()
                        2467 adobe_csi::CSXSEventQueueManager::PollEvents(vcfoundation::data::IVCString*, int)
                          2467 vcfoundation::thread::VCSynchronized::WaitFor(double)
                            2467 vcfoundation::thread::Monitor_os::WaitFor(double)
                              2467 vcfoundation::posix::PThread::cond_timedwait_relative(_opaque_pthread_cond_t*, _opaque_pthread_mutex_t*, timespec const*)
                                2467 pthread_cond_timedwait_relative_np
                                  2467 _pthread_cond_wait
                                    2467 semaphore_timedwait_signal_trap
    2467 Thread_8383
      2467 thread_start
        2467 _pthread_start
          2467 vcfoundation::thread::Thread::ThreadProc(void*)
            2467 vcfoundation::thread::AbstractThread::Run()
              2467 vcfoundation::ncomm::NCHost::Worker::Run()
                2467 vcfoundation::ncomm::NCHost::Worker::HandleRequest()
                  2467 vcfoundation::io::Serializer::Deserialize()
                    2467 vcfoundation::io::Serializer::InternalDeserialize()
                      2467 vcfoundation::io::Serializer::Read()
                        2467 vcfoundation::io::IVCChannel::ReadFully(void*, unsigned long)
                          2467 vcfoundation::io::BufferedReader::Read(void*, unsigned long)
                            2467 vcfoundation::io::BufferedReader::InternalRead(char*, long)
                              2467 vcfoundation::io::BufferedReader::Fill()
                                2467 vcfoundation::io::BSDNamedPipe::Read(void*, unsigned long)
                                  2467 vcfoundation::net::Bsd::Recv(int, void*, int, int)
                                    2467 recv$UNIX2003
                                      2467 recvfrom$UNIX2003
    854 Thread_14185
      854 start_wqthread
        854 _pthread_wqthread
          854 __workq_kernreturn
Total number in stack (recursive counted multiple, when >=5):
Sort by top of stack, same collapsed (when >= 5):
        accept$UNIX2003        2467
        mach_msg_trap        2467
        recvfrom$UNIX2003        2467
        semaphore_timedwait_signal_trap        2467
        kevent        2466
        __workq_kernreturn        855
Sample analysis of process 496 written to file /dev/stdout

Answer 1

Here's a sample from when it happens:
Sampling process 496 for 3 seconds with 1 millisecond of run time between samples
Sampling completed, processing symbols...
Analysis of sampling CS5ServiceManager (pid 496) every 1 millisecond
Call graph:
    2676 Thread_8368   DispatchQueue_1: com.apple.main-thread  (serial)
      2676 start
        2676 main
          2676 adobe_csi::ServiceManager::Run()
            2676 vcfoundation::system::IVCRunLoop::RunGUILoop()
              2676 -[NSApplication run]
                2676 -[NSApplication nextEventMatchingMask:untilDate:inMode:dequeue:]
                  2676 _DPSNextEvent
                    2676 BlockUntilNextEventMatchingListInMode
                      2676 ReceiveNextEventCommon
                        2676 RunCurrentEventLoopInMode
                          2676 CFRunLoopRunInMode
                            2676 CFRunLoopRunSpecific
                              2676 __CFRunLoopRun
                                2676 mach_msg
                                  2676 mach_msg_trap
    2676 Thread_8370   DispatchQueue_2: com.apple.libdispatch-manager  (serial)
      2676 start_wqthread
        2676 _pthread_wqthread
          2676 _dispatch_worker_thread2
            2676 _dispatch_queue_invoke
              2676 _dispatch_mgr_invoke
                2676 kevent
    2676 Thread_8373
      2676 thread_start
        2676 _pthread_start
          2676 vcfoundation::thread::Thread::ThreadProc(void*)
            2676 vcfoundation::thread::AbstractThread::Run()
              2676 vcfoundation::ncomm::NCHost::Server::Run()
                2676 vcfoundation::ncomm::NCHost::Server::Accept()
                  2676 vcfoundation::io::BSDPipeServer::Accept()
                    2676 vcfoundation::net::Bsd::Accept(int, sockaddr*, int*)
                      2676 accept$UNIX2003
    2676 Thread_8377
      2676 thread_start
        2676 _pthread_start
          2676 vcfoundation::thread::Thread::ThreadProc(void*)
            2676 vcfoundation::thread::AbstractThread::Run()
              2676 vcfoundation::ncomm::NCHost::Worker::Run()
                2676 vcfoundation::ncomm::NCHost::Worker::HandleRequest()
                  2676 vcfoundation::ncomm::NCHost::ExecuteRequest(vcfoundation::ncomm::INCHost::IRequest*)
                    2676 adobe_csi::AbstractRequest::Execute()
                      2676 adobe_csi::WaitForGlobalCSXSEventRequest::DoExecute()
                        2676 adobe_csi::CSXSEventQueueManager::PollEvents(vcfoundation::data::IVCString*, int)
                          2676 vcfoundation::thread::VCSynchronized::WaitFor(double)
                            2676 vcfoundation::thread::Monitor_os::WaitFor(double)
                              2676 vcfoundation::posix::PThread::cond_timedwait_relative(_opaque_pthread_cond_t*, _opaque_pthread_mutex_t*, timespec const*)
                                2676 pthread_cond_timedwait_relative_np
                                  2676 _pthread_cond_wait
                                    2676 semaphore_timedwait_signal_trap
    2676 Thread_8383
      2676 thread_start
        2676 _pthread_start
          2676 vcfoundation::thread::Thread::ThreadProc(void*)
            2676 vcfoundation::thread::AbstractThread::Run()
              2676 vcfoundation::ncomm::NCHost::Worker::Run()
                2676 vcfoundation::ncomm::NCHost::Worker::HandleRequest()
                  2676 vcfoundation::io::Serializer::Deserialize()
                    2676 vcfoundation::io::Serializer::InternalDeserialize()
                      2676 vcfoundation::io::Serializer::Read()
                        2676 vcfoundation::io::IVCChannel::ReadFully(void*, unsigned long)
                          2676 vcfoundation::io::BufferedReader::Read(void*, unsigned long)
                            2676 vcfoundation::io::BufferedReader::InternalRead(char*, long)
                              2676 vcfoundation::io::BufferedReader::Fill()
                                2676 vcfoundation::io::BSDNamedPipe::Read(void*, unsigned long)
                                  2676 vcfoundation::net::Bsd::Recv(int, void*, int, int)
                                    2676 recv$UNIX2003
                                      2676 recvfrom$UNIX2003
Total number in stack (recursive counted multiple, when >=5):
Sort by top of stack, same collapsed (when >= 5):
        accept$UNIX2003        2676
        kevent        2676
        mach_msg_trap        2676
        recvfrom$UNIX2003        2676
        semaphore_timedwait_signal_trap        2676
Sample analysis of process 496 written to file /dev/stdout