Mailbox move from 2007 to 2010 causes performance problems on the 2007 box AFTER the move

I'm having a problem where moving a mailbox from our 2007 Exchange server to our 2010 Exchange server is causing clients that are still on the 2007 server to lock up, sometimes for up to 20 minutes. This all happens maybe 5 minutes *after* the mailbox
move has completed - during the move we see no problems.
I start seeing events 5015, 5016, and then 10025 on the 2007 box and that's when users start complaining of Outlook locking up and emails going to Outbox.
If I do this off-hours like at night or on weekends I don't see the problem, which I'm sure is because there are far fewer clients connected. We do not use cached exchange mode for a variety of reasons but mainly because our document management software
doesn't play nicely with it.
I am leaning toward the disk structure of our 2007 server. They are fast (15k SAS) but arranged in a RAID-5 which isn't ideal, but which keeps up fine in all other cases. What is happening post-move that makes for so much disk activity? I
thought maybe if I moved a good chunk of users off the 2007 box off-hours it might make daytime moves more possible, but I just tried again and it all locked up just the same.
The details:
Exchange 2007 SP3 (15k SAS disks, 2x quad core Xeon E5345, 16GB RAM)
Exchange 2010 (VMware with 4 virtual cores, 16GB RAM, storage on EqualLogic SAN)
Clients are almost exclusively Outlook 2010 on Win7, though a handful of 2007 users remain.
We have about 240 users total, about 100 of which have moved to the 2010 system.
Thanks for any suggestions. I am stumped at this point.

Hi,
Based on my experience, the issue generally happens during the migration the old server didn’t get pulled from Active Directory correctly .
http://www.squidworks.net/2013/02/solved-event-ids-5015-5016-microsoft-exchange-2010-cannot-find-a-route-to-the-source-transport-server-or-home-mta-server/
Note: Microsoft is providing this information as a convenience to you. The sites are not controlled by Microsoft. Microsoft cannot make any representations regarding the quality, safety, or suitability of any software or information found there. Please make
sure that you completely understand the risk before retrieving any suggestions from the above link.
Thus, please check if the issue still can be reproduced after the migration.
If you have any question, please feel free to let me know.
Best regards,
Angela Shi
TechNet Community Support

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