My MBP has started to send out TCP packets larger than the MTU on the NIC - is there any place that this can be overriden?

Got a very weird issue here and wondering if anyone has any other ideas. Basically over the wired NIC only, my Mac has started to send out large HTTP/HTTPS packets from the browser (> 1500 bytes) Captures show packet sizes from 2000 all the way to 4000 sometimes. This happens in Firefox and Chrome so doesn't appear to be application related.
This causes fragmentation issues and traffic drops which basically causes most of my websites and  tools to crash and burn (and I get all sorts of SSL errors from applications, etc).
It appears to be limited to just TCP packets as pings with the DF bit set will not send any larger than 1500 bytes.
However if I switch to wireless, everything works fine and captures show the correct maximum packet size of 1500 for all packets leaving my client.
The MTU on the  en0 interface is 1500 as per ifconfig and I made sure that it was set to 1500 in Network config panel (because there is an option for jumbo frames there which bumps up the MTU).
A packet capture also shows that during the three way handshake the TCP MSS is successfully sent and negotiated as 1480, but then it appears to ignore that when sending packets later in the TCP stream.
I've rebooted, upgraded to 10.7.4, checked the "sysctl" outputs and matched against a Mac not having the issue.
This is the newest MBP 15 inch model.
Any other ideas on things to check?

Have you used any sort of "tuner" software? You are obviously an advanced user. Sometimes we hack things up and forget about it later. If you are sure you didn't do that, maybe poke around with IPv6 settings. Supposedly people are trying to enable that and it is going to be a disaster.

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