New domain, Roaming Profiles, Outlook 2010 gives error 'Your Outlook data file cannot be configured'.

Hi there,
I have recently setup a new domain, with a new domain controller and new exchange 2013 server.
these are running on a cluster of 2 x hyper-v 2012r2 hosts. All VMs are running server 2012 r2.
although I don't think that has any bearing on my issue.
I have migrated all of my existing user machines to the new domain.
We use roaming profiles.
When a user logs into their PC for the first time, all is ok.
when a user logs into a different machine (they log off of their first machine and then log into a second machine),
they get the following error when opening outlook.
'Your Outlook data file cannot be configured. C:\Users\%username%.domain\AppData\Local\Microsoft\Outlook\[email protected]'
I can manually resolve this on each machine by doing one of the following.
1. Before the user logs in, I log in as an administrator or browse to the pc from another machine create a folder in users called 'whatevertheuserssusernameis' (please note, I actually put in the user's username, ie OKIRWAN)
when the user then logs in, their profile is created in %username%.domain instead of %username%.
I believe this is the route of the problem, as when we added the new machines to the domain, and they logged in for the first time to their 'usual machine', there was already a folder in users with their username, so when we added to the new domain and logged
in for the first time, it created a new folder called %username%.domain, however when the user logs into a pc they never have logged into before, it creates their profile in %username% but their roaming profile is looking for their OST in C:\Users\%username%.domain\AppData\Local\Microsoft\Outlook\[email protected].
2. My second way around this is to go to control panel and mail and remove and recreate the users outlook profile.
As I have 100 users, who move to various different machines, these manual options are not really viable.
I have tried redirecting the OST file to c:\OST via group policy, this did not resolve the issue.
All users are local admins on their machines.
if I open outlook as administrator then it loads ok and creates the OST file in C:\Users\%username%.domain\AppData\Local\Microsoft\Outlook\[email protected].
however if I close outlook and open it again without running as administrator I get the following error.
File access is denied. You do not have the permission required to access the file C:\Users\%username%.domain\AppData\Local\Microsoft\Outlook\[email protected]. (even administrators on that PC have full access to that folder).
All users are running outlook 2010.
Any help would be much appreciated.
Kind Regards
Owen

Hi,
We can try to set up new profiles for users via creating a PRF file using the Office Customization Tool.
http://technet.microsoft.com/en-us/library/cc179062(v=office.14).aspx
Best Regards,
Steve Fan
TechNet Community Support

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