Persistent hang problem still unsanswered

SOMEBODY here must have a clue on this one. I've spent weeks on it myself, tried the local Apple Store, had a tune-up from a Mac repair shop and still ...
Periodically I will try to eject a CD from iTunes and the application will hang. When I Force Quit it's still there but won't do anything. Try to eject using Toast Titanium, which only causes IT to hang. Can't eject the disc from the finder; have to restart the computer.
Looking at the Console.log I find only this error:
Spamfire Agent: There was a Unknown error in QueueSynchronous.onAdvanceSMTPReportingItem.Process%%o<SMTPReportingItem> < SMTPReportingItem.#OnProcessInQueue%%o<SMTPReportingItem> < ProcessingMessage.processInQueue%%o<ProcessingMessage> < QueueS
[Spamfire Agent is part of my anti-spam app.]
At first I thought this was a RAM or USB bus problem. Had RAM and CPU checked out at Apple Store and they are A-OK. Removed my IOGear PCI USB card. No help.
For some reason the problem seems centered around audio-related apps: iTunes, Toast Titanium, and (sometimes) Peak Pro.

Honestly, when a system has lots of add-ons as your appears to have, you can get funky interaction which sometimes doesn't even seem logical.
What I do on my Macs is to create a test account, and when I install software that has the option, I only install for the main user account.
That makes troubleshooting much easier.
Another thing you can try is to boot into safe mode (shift key until login) and see if this persists.
BTW, Toast is up to version 8.0.1, do you have that update?
Scott

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