Problem with Adobe Reader and IE

I'm using Vista Home Premium and IE9 with the latest Reader available.  Starting yesterday, I cannot read PDF files on the web.  This is a new problem.  I tried to download newer versions of IE and the Reader, but both tell me I've got the newest versions I can use.
I have no problem with Firefox.  Just IE.  I prefer using IE.  Can someone guide me -- without using technical language.  Many thanks!!

Thanks for your input.  I opened the standalone Adobe Reader X, clicked Edit, Preferences, Security, Advanced Preferences.  Then clicked each of the 3 tabs on top, but nothing looked like "Protected Mode."
Then I went back and clicked Security (Enhanced) and unchecked Enable Enhanced Security.  Tested this change, but I still get the gray screen and messages:  "A problem has caused IE to close."  "A problem with this website has caused IE to close and re-open the tab."  I then went back and re-checked Enable Enhanced Security.
I should mention that I have used this particular website for about 10 years and never had a problem.  But I now have the same problem with any online PDF that I try to open using IE.
Can you think of anything else?  If not, here's my plan of attack.  Please let me know if you think it will work.
1)  Copy over all my favorite sites from IE to Firefox.  (I've already started doing that.)
2)  Uninstall IE and re-install it.
3)  If I still have a problem, uninstall Adobe Reader and re-install it.
Do you think this will do the job if all else fails?
Many, many thanks for the time you have put into this.

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