Send button grayed out

Hi,
I went to respond to an email today in Apple's Mail program and am not able to send the email. I am using my mobileme account. Basically I hit "Reply", write my email, and the go to press "Send" but the button is grayed out and inactive. I have never experienced this before so I am a bit puzzled. Mail is receiving emails still and is saving drafts locally that are syncing online so it does not appear to be a connection issue.

OK...I believe I have resolved the issue. My Mobileme SMTP server info disappeared. What would cause this information to disappear overnight?

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