Some apps wont open

Some apps like VLC, Skype etc. won't open. They show up in the dock and starts to bounce, but all they do is keep on bouncing for 1-2 minutes. I started up my Mac in SafeMode and then the applications worked just fine! So i think its some thirdparty application that messes with my apps. Any ideas?
Thanks in advance

hans.slang wrote:
I've tried reinstalling, and it doesnt work. No, I didn't back up. Do you think I should reinstall Lion and see what happens?
the only thing I might try is cleaning/rebuilding the user and system caches. Way in the dark ages of OS X (like 10.0 or 10.1) before I knew better I defragged. I fixed the problems by cleaning the caches. I tend to use the paid application TinkerTool System. But there are some free applications that can do it, like Onyx.
If that doesn't work, then yeah, what Grant said:
Grant Lenahan wrote:
maybe, an "archive and install" (or whatever they call it under Lion)
No backup..penny wise and pound foolish. Get thee a USB hard drive and cloning software (CCC suggested)
I forgot what they call it in Lion, it's a way of reinstalling the OS while leaving the old OS, applications, User directories, etc. on the HD. So you don't have to reinstall everything again.
Agree in principle with Grant about external HDs and backup/cloning software. I prefer Firewire because it's generally faster than USB. For clones I use SuperDuper! but Carbon Copy Cloner should be good to. I haven't used CCC in years.

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