TS2039 After saving an Excel document on my Mac ( I do have Office Mac), it will not reopen and gives error code -43. It will also say that there is no such file, although the file is in the document box. Has happened twice now with big files.

I work on Excel files through my Office Mac program. On two occasions, a large Excel file, (about 1.5 MB) will not save and is not recoverable. It gives me an error code -43.
I work on many such files without problem, but this has now happened on two occasions with important files.

If it only happens with very large spread sheets, and only happens randomly, then one possibility is a buffer overflow, i.e., some piece of data is so large as to clobber the data that follows it.  If that is the case then the problem would only manifest itself if (a) you happen to access that data, (b) write beyond its allocation, and (c) what's just beyond that gets clobbered is something involved with the file's pathname.  Then when the pathname is needed it can't be found resulting in the -43.
In other words, more "quality" programming from Microsoft...not.
Just a theory.

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