Acrobat 11 will never let me save changes to an existing file, only Save As

Every PDF file i try to mark up (highlights, comments, etc), I am unable to simply SAVE the changes.  Acrobat says "The file may be read-only, or another user may have it open.  Please save the document with a different name or in a different folder".  I have to use the Save-As function to save my work.  I need to be able to modify and existing file without creating a new instance of the same file.  This message appears regardless of the files location, the file, and no one else is using the document.
I have tried altering my set up in my preference, under document, to Never view documents in PDF/A  mode.  That did not help.  I uninstalled and then re-installed Acrobat.  I have tried the Repair Acrobat Installation function, I have checked for Errors, I have checked for updates, but nothing has helped. 
The strange part is that just my user on the computer has this problem.  I set up a second user for guests and that log-in has no issues saving a PDF file after it has been modified. 
I am Currently Using Adobe 11 on Windows 7 platform.  The computer is 1 month old.  But this problem has been present since the beginning.  I am set up as an administrator on the computer, so permissions are not an issue.
What do i have to do to fix this? 

Hi Jordan ,
It could be possible that somebody else is accessing the file as well as mentioned in the error message.
The second reason could be ,the creator of the file is someone else and the permissions have been set as read-only.
If possible please share the file with us so that we can have a look.
Regards
Sukrit Dhingra

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