Changing Item Description in Sales document through programmatically.

Hi
How to change the sales document Item Description programmatically.  I have one customization form, this will open when ever the user tabbed out from Quantity column. In that user form , user might be change the item description. I want to replace the sales document item description with the new one. if i manually replace it , the standard Item CFL will be automatically popup.
How can i resolve this?
Regards
Senthil

Hi petr,
Thanks for suggestion, I have already tried this, first of all i have change the Lines description and call the Ctrl+Tab functionality using sendkey method, but problem is after assigning the new description the system will open the CFL immediately.
Thanks
Senthil

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