Data Domain - Replication Acceleration vs Application Acceleration?

http://www.datadomain.com/pdf/DataDomain-Cisco-SolutionBrief.pdf
I recently read an article by Cisco detailing the WAAS appliances capability to add addional deduplicaion to Data Domain replication traffic being forwarded across the WAN. After reading the aricle and speaking with my SE. He recommended a 674 in Application Acceleration mode vs the WAE 7341 in Replication Acceleration mode. The article also states Application Acceleration mode was used.
Why is Application Acceleration mode recommended over Replication Acceleration mode for this traffic?
I have a project requiring 15 - 20 GB / day of incremental backups to be replicated between 3 sites. The sites are 90 ~ 110ms apart and the links are around 20mbps at each site. Would a 674 in Application Acceleration mode really make a difference for the Data Domain replications?

Is their any possibility you could dig up the configuration that was used on the WAAS Application Accelerator during the Data Domain testing. I see Data Domain replication service runs over port TCP 4126. My SE recommends disabling the WAE 674s DRE functions for the Data Domain traffic and simply reply on LZ & TFO. How do you simply disable DRE, but still use LZ and TFO?
I see 3 common settings;
action optimize full                                                       LZ+TFO+DRE
action optimize DRE no compression none          TFO only
action pass-through                                                    bypass
Can you do LZ+TFO only? None of the applications in the link below show this type of action setting. This leads me to believe my SE was really suggesting turn off DRE completely for the WAAS.
This WAAS needs to optimize traffic for;
Lotus-Notes, HTTP, CIFS, Directory Services, RDP, and Data Domain
Can all applications above + Data Domain be optimized from a pair of WAE 674s in AA mode?
http://cisco.biz/en/US/docs/app_ntwk_services/waas/waas/v407/configuration/guide/apx_apps.html
policy-engine application
   name Data-Domain
   classifier Data-Domain
      match dst port eq 4126
exit
   map basic
      name Data-Domain classifier Data-Domain action optimize DRE no compression LZ
exit

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