Exchange 2010 RPC over HTTPs failing with authentication error

Question

Hi.  I have my remote.xxx.co.uk domain and autodiscover.xxx.co.uk domain pointing to my SBS2011 server, have ports 25, 80, 443 open.  The Microsoft Connectivity Analyzer fails with the below error.
Outlook will autodiscover happily on the local network, and works fine.  Phones etc do too.
Outlook at a remote VPN connected site won't connect through autodiscover, but will if you do it manually (ignoring the RPC Proxy settings).  Everything works for a while, but then I guess outlook decides to use autodiscover to complete all the connection
details, and then these machines can no longer connect to exchange as I guess they decide the speed is too slow and try to connect using RPC instead.
Users can access OWA happily, and activesync is working on phones etc.
SSL cert is a wildcard type on my domain, and certs are installed - all green and happy when visiting OWA on both remote.xxxxx.co.uk and autodiscover.xxxxx.co.uk domains.
I cannot work out why I have an authentication error for RPC?
Any advice would be great!
Testing HTTP Authentication Methods for URL https://remote.xxxxx.co.uk/rpc/rpcproxy.dll?xxxxxx.xxxxxx.local:6002.
The HTTP authentication test failed.
Additional Details
Exception details:
Message: The operation has timed out
Type: System.Net.WebException
Stack trace:
at System.Net.HttpWebRequest.GetResponse()
at Microsoft.Exchange.Tools.ExRca.Extensions.RcaHttpRequest.GetResponse()
Elapsed Time: 100065 ms

Answer 1

Hi.
To update.
I tried to recreate the virtual directories in the Exchange Management Console, using the recreate links and via the shell, but while they were recreated, they did not function as they should due to issues in the meta database.
I then found the following which worked.
Looking at the ActiveSync virtual directories, when running the below command, the result showed the directory was there, so I then knew to delete it.
In EMS I ran,
=> Ran "$site = [ADSI]"IIS://localhost/W3SVC/1/Root/Microsoft-Server-ActiveSync""
Result: Carriage return.
=> Ran "$site"
Result:
distinguishedName:
Path: {C:\Program Files\Microsoft\ExchangeServer\V14\Client Access\Sync}
In EMS I then ran,
=> Ran "$Site = [ADSI]"IIS://localhost/W3SVC/1/Root""
Result: Carriage return.
=> Ran "$site.Delete("IIsWebVirtualDir","Microsoft-Server-ActiveSync")"
Result: Carriage return.
=> Ran "$site.SetInfo()"
Result: Carriage return.
=> Ran "$site"
Result: Carriage return.
=> Ran "iisreset"
I then recreated the virtual directories. 
In EMS I ran,
=> Ran "New-ActiveSyncVirtualDirectory -WebSiteName "Default Web Site""
Results: Successfully recreated.
=> Ran "iisreset"
I am not sure exactly, but I did this for multiple virtual directories, and everything came to life just as it should.