From design to print

I've been working with an 11x17 spread booklet layout within InDesign (brochure) and may be stuck in a bad habit. The majority of my work lately has been starting with RAW photography (after edits) saved as 300dpi hi-res psd files & placed in my spreads in ID (example: http://www.lifecareassurance.com/images/nov07.jpg . Well 6 pages of that & I'm looking at a 11,753mb pdf. The prints look perfect but the file size seems a bit high to me. I save as PSD PDF with standard compression with expert color for a high quality print on a 600dpi Canon image runner (C5180). As a test, I reduced the DPI of my images from 300 to 72 in PS leaving the actual dimensions the same. I don't see an obvious difference in quality within ID even in medium res view but, am I in-fact loosing quality by doing that? If so any suggestions for minimizing file size without compromising the quality. I have no problem with room on my server but, after 6 pages things slow down quite a bit.
Thanks!

Right, Well not only laser but full color professional printing as well. I realize that I can test via loop or visually to see differences, what i'm wondering is, there any definite proven loss of quality in clarity or color wise OR preferred method of prepping hi res images for placement in ID... All my graphics are linked of course. Placing them.. links them. I understand that having my view set as hi quality is an issue but it's not negotiable. Cropping un-used portions is another approach I've tried.. Sorry for the mis categorized topic. I swear I was in ID when I posted. Now I'm unable to delete or change category (or am I?)
Thanks for your time guys!

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