Hit Send Button - No Response, No Error message

After composing a message, I hit Send and the Mail app simply does not respond. It isn't frozen - no spinning ball or progress arrows - it just sits there. I have repaired/verified the disk and also repaired disk permissions. I have also created a new virgin user account with the same Mail settings and Mail WORKS FINE. So there appears to be a problem within this user account. I have also tried deleting the com.apple.mail.plist file - still no luck.
Any suggestions on how to proceed?

Can you compose the message normally in Mail? What is your Mail > Preferences > Composing > Check spelling setting? Set it to Never, restart Mail, and see whether that makes a difference. If it does, the problem is some Launch Services cache or preferences corruption that affects the ability of Mail to use the built-in spell checker.
The following article describes how to manually reset Launch Services — the notes at the bottom of the article also provide information about the side effects of deleting each of the files involved:
Resetting Launch Services
If you prefer using a cache cleaning utility instead of following the manual procedure described in the previous article, take a look at this other article for general troubleshooting and cache-cleaning procedures:
Resolving Disk, Permission, and Cache Corruption
The most appropriate utility for this particular problem probably is Tiger Cache Cleaner, but you may also want to consider other utilities, such as OnyX, or Cache Out X, which are free. Whatever utility you choose, be sure to read this first:
Side effects of System cache cleaning
As an example, this is how you should proceed with OnyX:
1. Quit all applications.
2. Launch OnyX and enter your administrator password.
3. Go to Maintenance > Reset and check LaunchServices database.
4. Un-check any other pre-checked options.
5. Click the Execute button.
6. Restart the computer.

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