How can I clean a mailbox and remove all but the latest message in thread, and more...

I am using Thunderbird version 24.6.0, for years I have been saving every email into a mailbox folder of a technical email alias I subscribe to.
The folder now has over 12,000 emails and I am exceeding 700 MB. Is there an Addon or tool of any kind that allows me to automatically in one fell swoop delete all but the last message in a thread assuming all prior messages included all prior messages in thread, BUT here's the hitch, if someone responded out of order to a thread or did not include prior messages, their message should be saved since it will not appear in the prior string of messages.
I can draw it out better than explain it, I want to save all responses to a thread, except those that are captured by the final message in a thread, or....
| Re:- topic1 a. don't save because all included in "c"
|- Re: topic1 b. don't save because all included in "c"
|- Re:topic1 c. save
| Re:- topic1 d. don't save because included in e.
|- Re: topic1 e. save
Thanks! ed

I have no idea on how, but your file needs to exceed 4Gb before there will be any kind of issue (and the guys think they have removed that limit not anyway)
Thunderbird will not move slowly or anything with lots of messages.

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