IMac suddenly so slow. 3.06GHz, 4GB RAM, OS X 10.7.3. Suddenly endless "cache-ing" going on, esp. when boot up, apps slow to open, 10 sec delay for keyboard hits to appear, colour "wheel" spinning on screen. Lots free HD space. What happened? Help!!

Suddenly so much "cache-ing" going on in the background, especially after boot-up.  But no new software downloaded recently, and plenty of HD space.
Apps now take long time to open, keyboard hits sometimes delayed by maybe 10 seconds before registering, the multi-colour spinning wheel often on screen, can hear hard drive whirring around endlessly in background.
What's happened?  Some sort of virus?  And how to fix, I wonder?  I'm using CleanMyMac and have run that several times, but has no effect.
Any help gratefully received.  Thanks.

Please take each of the following steps that you haven't already tried. Test after each one. Back up all data before making any changes.
1. Make sure that the right volume is selected in the Startup Disk preference pane.
2. Disconnect all wired peripherals except those needed to start up. If there's no change, reconnect them
3. Reset the System Management Controller.
4. Reset the PRAM.
5. Start up in safe mode, then restart as usual. If you can't start in safe mode—for instance, if FileVault is active—then triple-click anywhere in the line below on this page to select it:
/var/folders
Right-click or control-click the highlighted line and select
          Services ▹ Reveal
from the contextual menu. A Finder window should open with an item named "folders" selected. Move the selected item to the Trash. You'll be prompted for your administrator password. Restart and empty the Trash.

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