Is it possible to cluster appliances across different subnets?

We are attempting to cluster two appliances across different subnets in order to provide greater survivability. Although we were able to cluster the appliances, the manageability of the appliances has become somewhat impaired. We've opened ports 443, 22 and 2222 between the two appliances. The appliances are C350s running AsyncOS 7.1.3-010. Are we missing something?
Thanks,
Rob

Rob,
Are these appliances communicating using IP addresses? If yes, in order to a join cluster,using IP addresses there must be a reverse DNS  (PTR) record configured in DNS server for the Cisco IronPort appliance.Please check that if the the reverse lookup works. If not, it might be another issue.
Regards,
Jyothi Gandla
Customer Support Engineer

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