Issue opening Chrome and MS Office 2011 with OS X 10.9.3 update

I updated to OS X 10.9.3 on May 30th, and since then I'm unable to open any of the MS Office 2011 applications (installed locally). I also can't open Chrome.
Anybody else experiencing this?
Any recommendations on how to remedy?
Can I somehow uninstall 10.9.3 to see if that resolves the issue?

I did uninstall Chrome, downloaded again. It still won't open.
And yes, I do get an error message when i try to launch Chrome, Billings (an accounting app I use) and also with all Office apps. It is a really long error message, and it's a different error code every single time.
I upgraded from 10.9.2. And I have Office 14.3.X (I think 9). I'm guessing b/c I can't even see what version I have right now).
I'm uncertain about what to do at this point. I'm making a back-up using Time Machine so that I have a full backup.
Any advice about what to do>

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