Loss of audio after upgrade os x 10.7.5, reset PRAM, SMS, updated software and other recommendations i could find. Master volume sliders inactive in Audio Midi section. Can see sound bar responding it input on line in but is not being internally routed.

Recently upgrade to OS x 10.7.5 resulted in loss of what appears to be internal communication of line in audio, and output. Have tired several remedies including resetting PRAM, SMS, updating all software, multiple Sound and Audio Midi applications adjustments to no avail. Also no audio is recognized on USB mixing board I tried as well, though Audio USB Codec was displayed. THe master volume sliders and other options are greyed out on Audio Midi application whn I try to troubleshoot that. Nothing external will play through computer speakers, but internal sounds and iTunes play normally.I made sure the audio sampling rates were default. Software issue or soundcard/hardware failure.?..Pullin my hair out!

Might be corrupted sound preferences ...
Open the Finder. From the Finder menu bar click Go > Go to Folder
Type or copy paste the following;
/Library/Preferences/Audio
Click Go then move both .plist files from the Audio folder to the Trash.
com.apple.audioDeviceSettings.pllist
com.apple.audio.SystemSettings.plist
Restart your Mac. See if that made a difference ...

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