Mixed Manufacturing Strategies at Different Levels in BOM

Dear colleagues,
We have a situation where the BOM is about 5 levels deep. At the top level, the business needs a MTO type of solution. At the semifinished level i.e the assemblies need to be made after the receipt of sales order. Therefore, we can call the assembly level as either Assemble to order or Make to Order. However at subassembly level, forecasts are likely to be keyed in. Therefore, this is a make to stock.
We have some solutions that we have thought about so far.
1) I would like to hear if any of you have implemented multiple strategies within a single BOM structure and what challenges / issues you may have faced?
2) I would like to know if any you came across a situation where MTO production order in one level of BOM drives another MTO production order in another level?
3) What is the best way to manage and establish a hard pegging between different levels of BOM in R3? ( I know that this is easier in APO)
regards,
Pavan

We have implemented following scenario.
1st level - FERT - MTO strategy - type 20
2nd level - HALB - No strategy
3rd level - ROH/VERP - No strategy

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