Mixing memory sizes - any issues?

Have a 975x PUE with 2Gb Corsair memory in two memory slots. Consider installing 2*2Gb in the remaining slots i.e total 6Gb (Yes - I know you need to run a 64-bit OS to address this amount of memory). Is there any known problem? Plan to use same manufacturer and type of memory.

I've ran many boards over the years and have not one issue other than running memory made for overclocking with say value ram.  The overclocking memory just would run slow enough for the system and ended up dumping the value memory.  I see you currently have Corsair memory and if you stick in the same series and the same CAS range you may even be able to still overclock quite a bit if your lucky.  Unfortunately, you can't set your memory timings for each stick, it's a one speed for all four.  Just remember that they will only run as your slowest stick will allow.  I see yours are running at 4-4-4-12 and a lot of the 2 x 2gb sets are running those speeds lately.
Good luck
-=Mark=-
also, you can get different brands to work together, just make sure both companies are using the same chip manufacturers for best results.

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    Apologies, wrong thread, please ignore.
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