Mouse and kb unresponsive when system prefs quits

All works fine until I open system prefs for any reason. At that point I have to either keep it open or hard reboot my machine. If I actually quit system prefs (it doesn't crash mind you) my mouse will move but no clicks are registered and my kb is completely ignored. As I said, hard reboot is the only way out from there.
Looked through console msgs and can't find anything happening when the problem hits.
Any ideas?

The cache is mentioned several times in the report.
Go to ~/Library/Caches/com.apple.systempreferences
Move the Cache.db file from the com.apple.systempreferences folder to the Trash.
Restar your Mac.
~ (Tilde) character represents the Home folder.
For Lion:   To find the Home folder in OS X Lion, open the Finder, hold the Option key, and choose Go > Library

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