Mouse/keyboard stops responding

When I have stayed logged on, but switch to the login window, I have often experienced the sudden failure of the mouse and keyboard and unable to respond. The mouse does not show the red light and keyboard is unresponsive.
The clock still ticks off the seconds so the system is not totally frozen. No keyboard, mouse click will get the system to respond.
The only way I can get use back is after a forced shutdown. I have checked the connections and it doesn't appear to be a loose keyboard connection (mouse is connected to the keyboard)
I notice the problem more if I use the login option often and let the computer set on the login window for a while with my account still logged in. I keep mail running while in the login window mode. When I log back in the computer functions normally for a while then it stops suddenly while using the mouse or keyboard
The reason I use the login switch is that I have had a lot of problems of the computer going to powersaving mode and I can not wake it after being in that mode for several hours and would have to do a forced reboot. This inability to wake has been happening for several years.
G4 733 Quicksilver   Mac OS X (10.3.9)   1.12 GB ram

I'll put my Microsoft Wireless Desktop mouse/keyboard up against the competition any day. I can't say enough good things about the set. Got the pair for $50 at Costco.
My hands are too big for the notebook style keyboards found on macs and laptops and the extra space on the MS board is very welcomed. The function keys and the mouse have control panels of their own for configuring for global or specific application mapping of functions. The keyboard also interfaces with itunes (start/stop, fast forward, volume, pause), there are user selectable buttons for favorite application launchers, screen zoom, .............
The mouse has a toggle wheel that moves left/right which has definable actions for applications. In Mozilla it goes page forward/back. In Illustraor or Photoshop it pans left/right.
I have found that the mouse/keyboard actions work best in Mozilla/Firefox and don't work as well in Safari and, interestingly with Internet Explorer.
In short, I feel crippled by other keyboards.

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    @bsohal
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