Question of file size related to power point

I am a relatively new user to Premier Pro and currently have simple editing needs.  I am creating a powerpoint presentation in 2010 with multiple video clips (no audio).  The file size (powerpooint) has become too large (@ 300MB).  I plan to use a progam called Captivate to voice over the presentation.  This will then save and will be used on a secure webserver.  My concern is the file size will be unreasonable to download for the end user.  After much trial and error I chose to use WMV, H264p, 29.97 and changed the bitrate to 4000 to reduce the video size.  Other codecs would not show in powerpoint 2010 and quicktime created huge files.  I have 2 questions 1. any recommendations on reducing video file size without sacrificing quality (currently 1 min of video= @ 28MB).  Note I am using a fast blur to conceal patient's identity. 2. any suggestions on program similar to Captivate that may handle larger files for download.
I appreciate any guidance.
Thank you.

There's really only two ways to reduce the file size of a video clip - make it shorter, or reduce the bitrate.

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