SMTPD consumes all available RAM resources

Hi all,
I have a mail server that has extremely heavy disk activity after a few minutes of being booted, I have narrowed this down to heavy RAM usage by the SMTPD process.
In Activity monitor, multiple SMTPD processes are spawned, consuming up to 2GB of real memory each (server has 8GB of RAM).
The server keeps spawning these processes until there is too many, and it becomes unresponsive. As more spawn, the amount of real RAM used by each reduces, but the overall total remains the same.
I think each process should only be using 1-2MB per instance.
Server specs:
10.5.7 server, external XServe RAID connected via fibre channel holds the mail.
Connected to an OD system (not a replica).
OD master and replica sit on separate XServes, also running 10.5.7. Approx 1300 users on the OD server.
Is there a dud setting in /etc/postfix/master.cf or main.cf that may cause this, or is there something else at fault?
Any help greatly appreciated!
Cheers

I think I might have found the problem, there is a bunch of these entries in the log file:
CFPreferences: user home directory at /var/imap is unavailable. User domains will be volatile.
Called Apple and they said to re-select the mail store location in Server Admin -> Mail -> Settings -> Advanced -> Database
This seems to have done the trick, all the smtpd daemons are now only consuming around 1.8MB each, fingers crossed it stays this way!
I think there will be a kbase article posted about this soon.
Thanks for your help

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