Sound and my aging Mac Pro

So my Mac Pro (Early 2008) has had some odd sound issues lately – it doesn't have any.
Occasionally, when the sound goes out, if I try to increase the volume from the keyboard, the transparent volume icon that comes up has a mute symbol under the volume bars, which are all lit up. That only goes away if I switch the output to my MOTU Audio Express. I haven't hooked up headphones to that to see if I'm actually getting audio out through that (I don't have any headphones with a quarter-inch plug, but I suspect I am.
But this morning, I'm getting now sound, but the volume buttons on the keyboard are working normally, ie, the go up and down, but I still get no sound. Interestingly, I also notice that, everytime I go back to Sound preferences, the MOTU is selected, even after I put it on line out or internal speakers.
Is the onboard sound card failing? Do I just need to get a PCI sound card?
I have a feeling I'm going to have to replace this machine before too long. I'm trying to make it until the Mac Pro gets a proper update.

Thanks. I tried that, and went almost a week without the problem recurring, but it's back this morning. Slightly different, though. I can't adjust the volume from the keyboard (the mute symbol is back under the volume bars), but I CAN adjust the volume from System Preferences, and it Line Out stays selected there.
What's really strange, and this is new, is that, while I'm getting no sound in Safari, I am getting sound in Firefox. (This is either new, or I never thought to try Firefox before when this issue came up.) Not only that, though, I can't load YouTube videos in Safari. I get a "This video is currently unavailable" message, even though I can call up the same content in Firefox. I can't play mp3s, either. iTunes, similarly, won't produce sound. If I hit play, the speaker icon next to the song looks like it's playing, and the Play button turns to a Pause button, but no sound comes out and the time meter on the song doesn't advance.
I have no idea what to make of all this.

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    com.apple.driver.AppleUSBHIDKeyboard          170.2
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    com.apple.driver.AppleKeyStore          28.21
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    com.apple.iokit.IOACPIFamily          1.4
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