Unable to load DLL 'OraOps10w.dll': Access is denied.

Below is our error message. This happens around 5 - 7AM daily, and we are struggling with identifying the root cause. It's hard for me to believe it's code related, but anything's possible. Still, what's odd is the app runs fine for a day then an IIS reset is done and everything is fixed. Is there any way this could be related to code and has anyone dealt with this error before? Could a job or some permission being run behind the scenes be using this same dll and cause it to be overwritten?
Thanks, Bryan
Timestamp: 3/4/2010 12:11:23 PM
Message: HandlingInstanceID: 3d9a795c-1256-44c1-b018-f553d4023b12
An exception of type 'System.TypeInitializationException' occurred and was caught.
03/04/2010 07:11:23
Type : System.TypeInitializationException, mscorlib, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089
Message : The type initializer for 'Oracle.DataAccess.Types.OracleDecimal' threw an exception.
Source : Oracle.DataAccess
Help link :
TypeName : Oracle.DataAccess.Types.OracleDecimal
Data : System.Collections.ListDictionaryInternal
TargetSite : Void PostBind_Int32()
Stack Trace : at Oracle.DataAccess.Client.OracleParameter.PostBind_Int32()
at Oracle.DataAccess.Client.OracleParameter.PostBind(OracleConnection conn, OpoSqlValCtx* pOpoSqlValCtx, Int32 arraySize)
at Oracle.DataAccess.Client.OracleCommand.ExecuteNonQuery()
at Oracle.DataAccess.Client.OracleCommandBuilder.DeriveParameters(OracleCommand command)
at Microsoft.Practices.EnterpriseLibrary.Data.Odp.OdpDatabase.DeriveParameters(DbCommand discoveryCommand)
at Microsoft.Practices.EnterpriseLibrary.Data.Database.DiscoverParameters(DbCommand command)
Additional Info:
MachineName : MISTERC
TimeStamp : 3/4/2010 12:11:23 PM
FullName : Microsoft.Practices.EnterpriseLibrary.ExceptionHandling, Version=2.0.0.0, Culture=neutral, PublicKeyToken=3f0a163eed2abd49
ThreadIdentity :
WindowsIdentity : NT AUTHORITY\NETWORK SERVICE
Inner Exception
Type : System.DllNotFoundException, mscorlib, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089
Message : Unable to load DLL 'OraOps10w.dll': Access is denied. (Exception from HRESULT: 0x80070005 (E_ACCESSDENIED))
Source : Oracle.DataAccess
Help link :
TypeName :
Data : System.Collections.ListDictionaryInternal
TargetSite : Int32 AllocValCtxFromNoFmtStr(System.String, IntPtr ByRef)
Stack Trace : at Oracle.DataAccess.Types.OpsDec.AllocValCtxFromNoFmtStr(String numStr, IntPtr& numCtx)
at Oracle.DataAccess.Types.OracleDecimal.GetMaxValue()
at Oracle.DataAccess.Types.OracleDecimal..cctor()

Thanks a lot.
I give permissions to ASP.NET account in directory C:\Oracle\product\10.2.0\client_4 (full control) and the application running ok.

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