Upgrade for NAC to ISE - Config Changes

Hi,
I've a ready and wroking setup for Cisco NAC and i need to upgrade it to the new ISE, other than dot1x changes n the switches configurations, what else will need to be configured
does the upgrade makes it a fresh installation?

Yes, the NAC portion in ISE looks totally different from NAC since it's now working over Radius.
So I suggest you build a new setup with ISE in parrallel with your current production environment and test your config before doing the switchover.

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