Upgrading iPhone 4 firmware yields error -5000 during initial backup step

I am trying to upgrade my iPhone 4 firmware from v4.3.5 to v5.0.1 as offered by iTunes (v10.5.2.11 running on Windows 7).
When I do so, I first get a notification, that iTunes is first backing up all phone data in order to be able to restore it to the phone after the upgrade. After a few minutes I then get an alert popup, that the backup failed with error -5000 and the warning, that if I choose to continue, I will loose all data from my iPhone. At this point of course I always choose to abort (I repeated the process 3 times now, each time with the same result).
What is this "error -5000" and how can I fix or avoid it?  BTW: the computers HD has >75 GB left, so it can't be a space issue...
Michael
PS.: I thought I bought me an apple product to exactly avoid this kind of hassle and cryptic error messages...

I did as instructed (with mixed feeling I may add), but - alas - with the ame result, i.e. also with MSSE real time protection disabled I am getting the same "error -5000". I even rebooted (and then checked the setting again) to make sure it was really disabled before trying again.
Other options or suggestions?
Michael

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