Users lose connection to Exchange.

Hi
I have a Exchange 2007 on Windows 2003 environment with  about 9,000 users.
Lately I have been struggling with an issue and I need some help.
Some users lose their connectivity of Outlook to Exchange (outlook appears Offline), even though they have Network connection and normally to solve this, I disconnect the network cable and reconnect it. I just want to clarify if this is a network or Exchange
issue and also, how could I solve this.
Thanks.

1) If unplugging the network cable to the user's computer and plugging it back in again fixes the issue, it is probably not a, server issue.
2) However, to test, can the user access OWA while their Outlook is unable to connect? If so, their mailbox is fine.
3) How are you configuring Outlook to connect - RPC/TCP or RPC/HTTP (OutlookAnywhere)?  RPC/TCP will connect directly to the Mailbox server with Exchange 2007 and OutlookAnywhere will connect to the CAS server, so it is important to distinguish which
connection you are troubleshooting.
4) What is common about the group of users who lose connectivity? Same switch? Same Database? Connecting to same CAS (if OutlookAnywhere)?
5) Do some basic network connectivity tests (ping, tracert, nslookup, etc) on the PC when in repro
6) Collect and analyze a netmon capture during the issue.
EDIT:
Also, from a client perspective - take a look at event logs.   Also, is AV installed and does the issue occur if you uninstall or disable it temporarily?

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