Wired memory does not clear after safe boot

Question

My iMac started freezing up about a month ago when I was watching a video and would only boot up in safe mode. I noticed in Activity Monitor that 5.30 GB of memory was "wired" (out of 8 GB total). I was able to boot normally after cleaning the caches.
The problem has gotten worse and the iMac now freezes after a short while of playing video.  As of now I can ONLY boot up in safe mode and Activity Monitor always shows 5.30 GB of wired memory, however no processes are using more than 1% of CPU (other than Activity Monitor itself). 
Today I downloaded and tried a couple of memory cleaner apps just so I could reboot normally, but the wired memory (5.30 GB) won't budge.  After doing some research I learned about the kextstat command to see what memory is being wired.  This is the process using the most memory (assuming that longer numbers are the largest):
71    0 0xffffff7f80e98000 0x1aa000   0x1aa000   com.apple.kext.AMD4800Controller (8.1.2) <70 69 10 9 5 4 3 1>
Also, here are the last 2 lines from the SYSTEM LOG just before the freeze (each line was repeated 7 times):
7/2/13 12:44:23.325 PM coreaudiod[272]: Enabled automatic stack shots because audio IO is inactive
7/2/13 12:45:21.280 PM coreaudiod[272]: Disabled automatic stack shots because audio IO is active
Any suggested next steps in troubleshooting are appreciated.

Answer 1

Please read this whole message before doing anything.
This procedure is a diagnostic test. It won’t solve your problem. Don’t be disappointed when you find that nothing has changed after you complete it.
Third-party system modifications are a common cause of usability problems. By a “system modification,” I mean software that affects the operation of other software — potentially for the worse. The following procedure will help identify which such modifications you've installed. Don’t be alarmed by the complexity of these instructions — they’re easy to carry out and won’t change anything on your Mac.  
These steps are to be taken while booted in safe mode.
Below are instructions to enter some UNIX shell commands. The commands are harmless, but they must be entered exactly as given in order to work. If you have doubts about the safety of the procedure suggested here, search this site for other discussions in which it’s been followed without any report of ill effects. 
Some of the commands will line-wrap or scroll in your browser, but each one is really just a single line, all of which must be selected. You can accomplish this easily by triple-clicking anywhere in the line. The whole line will highlight, and you can then copy it. The headings “Step 1” and so on are not part of the commands. 
Note: If you have more than one user account, Step 2 must be taken as an administrator. Ordinarily that would be the user created automatically when you booted the system for the first time. The other steps should be taken as the user who has the problem, if different. Most personal Macs have only one user, and in that case this paragraph doesn’t apply. 
Launch the Terminal application in any of the following ways: 
☞ Enter the first few letters of its name into a Spotlight search. Select it in the results (it should be at the top.) 
☞ In the Finder, select Go ▹ Utilities from the menu bar, or press the key combination shift-command-U. The application is in the folder that opens. 
☞ Open LaunchPad. Click Utilities, then Terminal in the icon grid. 
When you launch Terminal, a text window will open with a line already in it, ending either in a dollar sign (“$”) or a percent sign (“%”). If you get the percent sign, enter “sh” and press return. You should then get a new line ending in a dollar sign. 
Step 1 
Triple-click the line of text below to select it:
for k in {,/S*}/L*/E*/{,.?}*.kext; do test -f "$k/Contents/Info.plist" && /usr/libexec/PlistBuddy -c "Print :CFBundleIdentifier" "$_" | egrep -qv "apple|Accusys|ArcMSR|ATTO|CalDigit|HighPoint|hp-fax|JMicron|print|SoftRAID|stex" && echo $k; done | open -f -a TextEdit
Copy the selected text to the Clipboard by pressing the key combination command-C. Then click anywhere in the Terminal window and paste (command-V). A TextEdit window will open with the output of the command. If the command produced no output, the window will be empty. Post the contents of the TextEdit window (not the Terminal window), if any — the text, please, not a screenshot. You can then close the TextEdit window. The title of the window doesn't matter, and you don't need to post that. No typing is involved in this step.
Step 2 
Repeat with this line:
sudo defaults read com.apple.loginwindow LoginHook 2> /dev/null | open -f -a TextEdit
This time you'll be prompted for your login password, which you do have to type. Nothing will be displayed when you type it. Type it carefully and then press return. You may get a one-time warning to be careful. Heed that warning, but don't post it. If you see a message that your username "is not in the sudoers file," then you're not logged in as an administrator. 
Note: If you don’t have a login password, you’ll need to set one before taking this step. If that’s not possible, skip to the next step. 
Step 3 
Repeat with this line:
ls -1A /e*/{la,mach}* {,/}L*/{Ad,Compon,Ex,Fram,In,Keyb,La,Mail/Bu,P*P,Priv,Qu,Scripti,Servi,Spo,Sta}* L*/Fonts .la* 2> /dev/null | open -f -a TextEdit
Important: If you formerly synchronized with a MobileMe account, your me.com email address may appear in the output of the above command. If so, anonymize it before posting. 
Step 4
osascript -e 'tell application "System Events" to get name of every login item' 2> /dev/null | open -f -a TextEdit 
Remember, Steps 1-4 are all copy-and-paste — no typing, except your password. Also remember to post the output. 
You can then quit Terminal.