Unable to access OWA or ECP. - "Something went wrong" or "500 unexpected error"

Question

Our environment consist of 3 client access servers with 8 mailbox servers.  I recently installed windows updates on all of the servers.  Now when a user tries to access OWA it fails and says "Something went wrong" when I try to access
ECP I receive "500 unexpected error"
I have tried building a new CAS and mailbox servers with the default settings but it still fails.  I did not install the latest Windows updates on the new servers.  I tried creating new databases with new users and it also fails.  
There are also these ASP.NET 4.0.30319.0 warnings showing in the application log:
Log Name:      Application
Source:        ASP.NET 4.0.30319.0
Date:          8/30/2013 11:02:13 AM
Event ID:      1309
Task Category: Web Event
Level:         Warning
Keywords:      Classic
User:          N/A
Computer:      FacultyEmail01.corjesu.org
Description:
Event code: 3005 
Event message: An unhandled exception has occurred. 
Event time: 8/30/2013 11:02:13 AM 
Event time (UTC): 8/30/2013 4:02:13 PM 
Event ID: 1088bfe111264e01b536f66f2591c15a 
Event sequence: 48245 
Event occurrence: 1597 
Event detail code: 0 
Application information: 
    Application domain: /LM/W3SVC/2/ROOT/owa-1-130223042171473642 
    Trust level: Full 
    Application Virtual Path: /owa 
    Application Path: C:\Program Files\Microsoft\Exchange Server\V15\ClientAccess\owa\ 
    Machine name: FACULTYEMAIL01 
Process information: 
    Process ID: 13764 
    Process name: w3wp.exe 
    Account name: NT AUTHORITY\SYSTEM 
Exception information: 
    Exception type: NullReferenceException 
    Exception message: Object reference not set to an instance of an object.
   at Microsoft.Exchange.Clients.Common.Canary15.Init(Byte[] userContextIdBinary, Byte[] timeStampBinary, String logonUniqueKey, Byte[] hashBinary, String logData)
   at Microsoft.Exchange.Clients.Common.Canary15..ctor(String logonUniqueKey)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpCookie(HttpCookie cookie, String logonUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpContext(HttpContext httpContext, String logOnUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.InternalOnPostAuthorizeRequest(Object sender)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.OnPostAuthorizeRequest(Object sender, EventArgs e)
   at System.Web.HttpApplication.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute()
   at System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously)
Request information: 
    Request URL: https://localhost:444/owa/logoff.owa 
    Request path: /owa/logoff.owa 
    User host address: 127.0.0.1 
    User: CORJESU\SM_cab26786a5604c759 
    Is authenticated: True 
    Authentication Type: Kerberos 
    Thread account name: NT AUTHORITY\SYSTEM 
Thread information: 
    Thread ID: 12 
    Thread account name: NT AUTHORITY\SYSTEM 
    Is impersonating: False 
    Stack trace:    at Microsoft.Exchange.Clients.Common.Canary15.Init(Byte[] userContextIdBinary, Byte[] timeStampBinary, String logonUniqueKey, Byte[] hashBinary, String logData)
   at Microsoft.Exchange.Clients.Common.Canary15..ctor(String logonUniqueKey)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpCookie(HttpCookie cookie, String logonUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpContext(HttpContext httpContext, String logOnUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.InternalOnPostAuthorizeRequest(Object sender)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.OnPostAuthorizeRequest(Object sender, EventArgs e)
   at System.Web.HttpApplication.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute()
   at System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously)
Custom event details: 
Event Xml:
<Event xmlns="http://schemas.microsoft.com/win/2004/08/events/event">
  <System>
    <Provider Name="ASP.NET 4.0.30319.0" />
    <EventID Qualifiers="32768">1309</EventID>
    <Level>3</Level>
    <Task>3</Task>
    <Keywords>0x80000000000000</Keywords>
    <TimeCreated SystemTime="2013-08-30T16:02:13.000000000Z" />
    <EventRecordID>721791</EventRecordID>
    <Channel>Application</Channel>
    <Computer>FacultyEmail01.corjesu.org</Computer>
    <Security />
  </System>
  <EventData>
    <Data>3005</Data>
    <Data>An unhandled exception has occurred.</Data>
    <Data>8/30/2013 11:02:13 AM</Data>
    <Data>8/30/2013 4:02:13 PM</Data>
    <Data>1088bfe111264e01b536f66f2591c15a</Data>
    <Data>48245</Data>
    <Data>1597</Data>
    <Data>0</Data>
    <Data>/LM/W3SVC/2/ROOT/owa-1-130223042171473642</Data>
    <Data>Full</Data>
    <Data>/owa</Data>
    <Data>C:\Program Files\Microsoft\Exchange Server\V15\ClientAccess\owa\</Data>
    <Data>FACULTYEMAIL01</Data>
    <Data>
    </Data>
    <Data>13764</Data>
    <Data>w3wp.exe</Data>
    <Data>NT AUTHORITY\SYSTEM</Data>
    <Data>NullReferenceException</Data>
    <Data>Object reference not set to an instance of an object.
   at Microsoft.Exchange.Clients.Common.Canary15.Init(Byte[] userContextIdBinary, Byte[] timeStampBinary, String logonUniqueKey, Byte[] hashBinary, String logData)
   at Microsoft.Exchange.Clients.Common.Canary15..ctor(String logonUniqueKey)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpCookie(HttpCookie cookie, String logonUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpContext(HttpContext httpContext, String logOnUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.InternalOnPostAuthorizeRequest(Object sender)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.OnPostAuthorizeRequest(Object sender, EventArgs e)
   at System.Web.HttpApplication.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute()
   at System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean&amp; completedSynchronously)
</Data>
    <Data>https://localhost:444/owa/logoff.owa</Data>
    <Data>/owa/logoff.owa</Data>
    <Data>127.0.0.1</Data>
    <Data>CORJESU\SM_cab26786a5604c759</Data>
    <Data>True</Data>
    <Data>Kerberos</Data>
    <Data>NT AUTHORITY\SYSTEM</Data>
    <Data>12</Data>
    <Data>NT AUTHORITY\SYSTEM</Data>
    <Data>False</Data>
    <Data>   at Microsoft.Exchange.Clients.Common.Canary15.Init(Byte[] userContextIdBinary, Byte[] timeStampBinary, String logonUniqueKey, Byte[] hashBinary, String logData)
   at Microsoft.Exchange.Clients.Common.Canary15..ctor(String logonUniqueKey)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpCookie(HttpCookie cookie, String logonUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Common.Canary15Cookie.TryCreateFromHttpContext(HttpContext httpContext, String logOnUniqueKey, Canary15Profile profile)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.InternalOnPostAuthorizeRequest(Object sender)
   at Microsoft.Exchange.Clients.Owa2.Server.Core.OwaRequestHandler.OnPostAuthorizeRequest(Object sender, EventArgs e)
   at System.Web.HttpApplication.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute()
   at System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean&amp; completedSynchronously)
</Data>
  </EventData>
</Event>

Answer 1

I opened a case with Microsoft.  After 3 days and over 15 hours on the phone they were able to resolve the problem.  They had to use ADSI edit to remove the canary data for the domain.
I tried rebuilding the virtual directories, building a new CAS server, a new mailbox server and a new server with both roles installed.  I created a new database and new users in that database and used the new CAS server but the problem continued which
led us to believe it was something being obtained from Active Directory.  We finally figured out the problem was in the properties of an object in ADSI. 
You have to open the ADSI editor on the primary domain controller (start-->administrative tools-->ADSI edit), go to CN=Services --> CN=Microsoft Exchange --> CN=<Your Site Name>  Right click CN=Client Access and click properties. 
Scroll down to msExchCanaryData0.  You have to click edit and copy the data from Data0, Data1 and Data2 (you may have more or less) to a notepad file.  Then erase the data from those settings.  Now log onto the CAS server and open IIS management. 
Go to application pools and  right click MSExchangeOWAAppPool and click Recycling.  Then restart all of the mailbox servers.  
It's a great idea to take a system state backup before performing these steps as editing ADSI data is risky.