Blinking file and question mark does not go away

My imac is constantly showing this blinking file with a questionmark when starting it. I tried all kinds of things to bring it back to life, like cmd + R, holding the shift button, c button and other stuff but none of them works. Could anyone plese help?

I take it you don't currently have backup to an external disk - Time Machine or a clone?
Here's some instructions for backing up, although you need a working Mac to be able to do it. Obviously, this shows how vital it is to always keep current backup so you have a recovery plan before disaster strikes:
http://support.apple.com/kb/ht1553
Hopefully you won't need to erase your data - repairing the disk, or simply re-installing the OS should not erase anything. Only an erase and install does that. You'll need backup if it turns out your hard disk is kaput (possible).
If the Mac currently has either 10.8 or 10.9 installed does booting using Command+r not do anything?
If it doesn't you can try putting the Leopard disk in the drive and booting holding Command + c - hopefully it'll boot and allow you to run Disk Utility to check/repair the disk - NOT to re-install the OS. If it does boot, at the first screen select your language and from the next screen, from the menu bar, select Utilities>Disk Utility. Select Macintosh HD>Repair Disk. If anything gets fixed click on repair disk again until you get a clean pass. Once done restart as normal from the Apple menu.
If all that comes to nothing I think it's off to the repair centre.

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