Can a SQL Cluster have many Master Secret \ SSO systems?

We are trying to build a BizTalk environment that will offer multiple BizTalk instances off one SQL cluster.
Our SQL cluster consists of 2 servers configured in an ACTIV\ACTIVE configuration and reads data from a SAN.
We have to set up 6 BizTalk instances to create 6 environments for UAT, Support, DR, etc. These BizTalk groups will contain 2 BizTalk servers each. Each instance will have a group of service accounts assigned to it ino order to separate the environments
but will still use the same SQL cluster.
We have named cluster resources for each UAT, Support, etc for the SAN so that the databses are written and read from mounted disks.
My question and confusion surrounds SSO and the clustering of the Master Secret for multiple instances.
I want to cluster the Master Secret on the existing SQL cluster as the documentation states, but I am not sure if this is correct when there are multiple BizTalk instances running off the the same SQL cluster. The nodes of the SQL cluster will have
the SSO service installed and so too will the BizTalk servers in each instance group - UAT, Support, etc. So, would this mean there is only one master secret being used for all BizTalk instances, which I feel is wrong?
Or should the master secret just exist on a bizTalk server without HA?
I want HA but not sure where the SSO and master secret should go and ensure there are no dependencies from the other BizTalk instances should the SSO service need restarting on the SQL cluster.
I have not implemented multiple instances on the same SQL cluster before so this is new and confusing. The microsoft documentation isn't too great either.
Any help and guidance would be greatly appreciated.

post Windows Server 2008 you can have multiple MS DTC instances on one cluster. So unlike previous versions (w2k3) where the recommendation was to add MSDTC to the base cluster group, you can now have one instance of MSDTC cluster resource per resource group.
In short yes if you feel that MSDTC is becoming a bottleneck in your processing. Also it would be preferred that for each of your BizTalk Environments you create at least ONE MSDTC resource per environment.
Regards.

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Hii All,
We are having one sql server on cluster which behaves like Master secret server and three biztalk application server , when we take restart on Master server of entsso is it nesscary to have take start on ENTSSO.
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Hi Mangla,
When you restart the Master secret server or when
master secret server becomes unavailable, then BizTalk Server host instances can still perform run-time operations by using the in-memory cached copy of the master secret
until:
The host instances are restarted.
The SSO service on the computer running the BizTalk host instances is restarted.
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Can a SQL Cluster have many Master Secret \ SSO systems?

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