Can I format and use a Hard Drive for my mac if removed from a Desk Top PC

Hi All,
I wondered if you can help with some advise. I have a mackbook and love it, will never go back to pc. But, I have a desk top pc with a fairly sizable Hard Drive in it. Even though I also have a WD external Hard Drive for my macbook back up, would I be able to use my old desk top hard drive if I found a case for it to make it an 2nd external hard drive?
Would I be able to format it for use with my mac? Or is it the bin for all the hardware?
Thanking you in advance.
Matt

It'd work just fine. Apple uses pretty much the exact same parts every other computer maker does. The one exception is now they have a temp sensor cable connection built onto drives. Before they just stuck a little plastic clip on them at a specific spot. Other than that, it's no different from any other SATA drive you might buy at the likes of Best Buy or NewEgg. So as long as you partition the drive into a format readable by Mac OS X, there shouldn't be any problems.

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