Forefront disappearing from Lab computers

I'm an administrator for Gonzaga University School of Business computer labs. We have had Microsoft Forefront installed on our Windows 7 Enterprise lab machines for several years. We have just noticed that Forefront is disappearing from random
computers. Not just one or two but upwards of 100 computers.
The symptoms are:
The Forefront icon is missing from the systray.
The program icons are missing from the Program menu.
If I do a search from the Start button, I find an unresolved icon for Forefront. Clicking on it tells me there is no program associated with it.
In the Programs And Features program list, there is an unresolved icon.  Clicking on it to do an uninstall produces a message to the effect that the program has already been uninstalled, and do I want to remove the icon from the list.
I'm wondering if you know of any legitimate events that could cause this to happen.
Thanks,
Rob Joyce

That kind of sounds like the behavior of a malware infection that is preventing Endpoint Protection from running...
Check HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Run in the registry
Has the MSC property been altered? It should be
"c:\Program Files\Microsoft Security Client\msseces.exe" -hide -runkey
I've seen cases before where this is altered to something like mssecesx.exe so the EP interface can't launch.
I may be off track in this case, but I've seen this before on systems infected with the Sirefef/ZeroAccess malware. It's worth checking anyway.

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