How do you reduce file size of a PDF if Save As doesnt work?

I have been trying to reduce the size of a PDF, using the Save As > Optimized PDF method.
I have also tried Save As > Reduced Size PDF.
This is on a file made up of 20 pages of full page Jpegs. (These were generated by the script in Photoshop that generates Jpeg files from Layer Comps within the document.)
If I use Reduced Size PDF, I get a greatly reduced file size but the image quality suffers greatly. (Lots of artifacts and blurryness)
There are no options to choose the level of compression I want.
If I use Optimized PDF method, I cant seem to reduce the file size no matter what I set the Jpeg compression to.
Is there some way to cut the size of the file down but not lose so much image quality?
Any suggestions?

Part of the problem here is that the files that are produced when I run the script to output files from layer comps are very big.
If I "save for web" for each layer comp, I wind up with way smaller Jpegs. Thus a much smaller PDF.
So the question is: Can you make the script, Layer Comps to Files, create smaller more optimized Jpegs? (Like you get when you save for web)

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