Indesign CS4 really slow with CMYK images

Can anyone help me solve this? InDesign CS4 document with a few pages, and approx 24 images on a page. With CMYK images imported the rendering and re-rending is very sluggish. The Processes shows 99% usage for InDesign. Makes it almost impossible to work on a document.
Any ideas to fix this?
I'm using an 27" iMac with 2.8 GHz Intel Core i7 - Memory: 8GB 1067 MHz DDR3

Doesn't surprise me. I find getting help in Adobe forums/support/community very confusing to find my way around.

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    I guess this could be just Chrome initializing some code, but still seems really high. Not the end of the world, but annoying anyhow. Anyone hit similar issues or any other ideas?
    Generator code
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    Panel javascript:
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    $.ajax({ url: "http://127.0.0.1:8080/service", async: true })
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    Might be Chrome/panel init delay. If you keep Photoshop&panel open and kill & restart Generator, there is no delay. But if Generator is running, closing & opening panel gives the delay every time. In any case panel side seems to be "guilty".

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