Mavericks can't use my macpro anymore....too slow

Hi eveyone,
I got huge problems since yesterday, my macpro as several problem like becoming very very very slow.
I have this wheel coming every seconds, opening a windows take 1 mn minimum,etc.... I check the hard drive but it seem to be ok.
I tried to verify permission but after one day it´s still not finish....this morning i noticed that spotlight was indexing,but because i reboot, spotlight do not index anymore but the problem(all is slow) is still present.
Yesterday, i also noticed that time machine did not save since one day too.
I also think spotlight and imessage do not work properly anymore ( spotlight do not recognize keychain app by example & Imessages do not recognize anybody anymore....
I have to say that i uploaded Mavericks for 1 weeks and it worked OK untill yesterday. I just had few small problem with keychain( com.apple.IcloudHelper.xpc want to use keychain 10 time by day) but that's all.
Anyhelp would be much appreciated cause i can't work at all now.
Thanks

Update:
I tried many things but i still didn't find the problem, my mac is still very slow ( it take about 30 sec/1mn  to open a window....)
What i did was:
- i download onyx for mavericks but each operation is very slow and often the process freeze before the end)
- i stop spotlight indexation ( never ending)
- i stop all timemachine process ( too long and never ending )
- i stop internet wifi connection
- i have verify permissions and disk ( restart +Cmd R) > All is OK
- in the monitor activity , i don't see any strange activity
- i change user session but it's the same...
If anyone could give an idea to explore ! It look like a disk problem but it´s not ( onyx smart test is OK too !!!)
HELP !!

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