Outlook 2013, intermittent "exchange server not avaliable"

I have a virtualised environment.
----The setup:-----
two vHosts, vmware 5.5, 4 CPU, 196 GB RAM, Storewize v3700, 20 10K disks in RAID10
two win 2012 exchange 2013 servers
two win2012 DCs
five (5) Win2008R2 RDS hosts + 1 2008R2 Connection broker
60 users on the RDS server in outlook online-mode. no cache
Office 2013 on the servers
-----the problem:---
Some random users have random problems opening outlook.
A user tries to open outlook and gets the message "exchange server not avaliable".. he says OK, and outlook closes. - opens outlook again, and everything works..
This happens at random times for random users
CPU, disk and network activity are very low on both vhosts and there is a lot of avaliable RAM on all guests
I don't know if its related, but the larger the mailbox is, the longer it takes to open outlook.. some times up to 6-10 seconds.. At idle times, outlook opens in less than a second..
Any ideas?

Hi,
According to your description, the issue randomly happens on random users and all users use online mode. Thus, I recommend you use performance monitor to double check if the issue is caused by performance and we can also check if there is any 9646 error
code in the event log.
http://technet.microsoft.com/en-us/library/dd335215(v=exchg.141).aspx
We can use performance monitor to check the change of the counters: RPC request, RPC average latency and RPC operation/sec
Referring to others’ suggestions, the issue may be caused by E1000 vNICs. Maybe we can temporarily try to update to E1000e. Alternatively, you can ask for help from the VMAS support.
If you have any question, please feel free to let me know.
Thanks,
Angela Shi
TechNet Community Support
Thanks for your reply Angela.
The vNICs are already E1000e. The next step for me is to try upgrading them to VMXNET3.  There are no errors in the event log related to this. I have not yet gone the perfmon-way, because I figured that when disk activity and CPU / RAM consumption is
so low, it wouldn't be an issue.
I was connected to the system yesterday evening where I experienced this error. There were a total of 8 users connected to the system, having only the ERP system running. I was the only user on that particular RDS host, and vmware performance metrics say
the servers are under very low load-level..

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    It's recommended to download and install
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