Photoshop Says .psd file is invalid

Photoshop keeps saying my psd file is invalid and refuses to open it. I am not sure why it is doing this. The last time  I was able to open
the document, I saved it sucessfully.  I am using photoshop CS 5.1 Extended

Sometimes a file gets corrupted in the save process.  Try opening in another program like Irfanview.  Once open save and see if PS will open.

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