Scalable / Available Architecture for Legacy Connectivity

In general, what is the most scalable and maintainable approach to real-time / near-time legacy data integration (i.e. with a public facing web site)?
A couple thoughts:
Use a JDBC / JCA connection synchronously ...
Use JNI to a native library connection & custom socket connection pool, synchronously ...
Use JMS queue and a service to fulfill queued requests asynchronously, and have the service work through JDBC, JCA, or a native library ...
non-functional requirements are
(1) scale to support peak volumes of 20-30 txn / sec (now) ... possibly up to (40-50) txn (future)
(2) 99.5+% availability

JDBC / JCA connection synchronously
synchronously says most of what you need to hear about scalability. if you have enough and don't mind wasting threads then this works, but the more threads, the more context switching, and you are limited in your concurrency.
JNI
definitely fast, difficult to maintain, difficult multiplexing issues to get it right
JMS
asynchronous, inbetween JDBC and JNI for the speed. Good concurrency. The key here is the concurrency and elasticity that you get with an asynchronous queue.

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