TS3276 Email response went to outbox, tried to resend and email freezes..will not allow cancellation, or any other action.  How do I unfreeze my email.

Email response went to outbox, tried to resend and email freezes..will not allow cancellation, or any other action

Was this an unusual mail message in any way, such as a message with a very large attachment?  If so, it may not be permitted by the mail server.
If you mean that all of Mail.app is currently wedged, then option-click (and hold) on the Mail.app icon in the dock and (when the popup appears) select force quit. 
If Mail.app is not wedged (and if it's just this message that's stuck), then ignore this and don't force-quit mail.  Just Quit from mail.
Take your network offline.  (If Mail.app is working, you can take all your mail accounts offline, but shutting off WiFi or removing your wired connection will work well enough for the purposes here.)
Relaunch Mail.app and select Mailbox > Rebuild from the menu.
Then select the Window > Connection Doctor from the menu, and see if any errors are reported.
Then nuke the message.
Then reconnect your network, or take your mail accounts back online.

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