How to troubleshoot failing applications or user profiles

Hi,
I have a very curious issue. I am running Adobe Lightroom 3.3 64 bit mode for quite some time now.
However two days ago it fails to startup, and although it doesn't use a lot of processing power (activity monitor), my laptop is very slow and almost unresponsive when it happens.
Running Lightroom in 32 bit mode is fine, but also running it when logged in as another user in both 32 and 64 bit mode goes well.
I have also ran Mac OS X 10.6.5. in 32 and 64 bit mode, but the same issue here.
So I suspect the issue has something to do with my user, and not with the application itself.
How can I troubleshoot my userprofile?
Hope someone can help me out!
Kind regards,
Roeland

Thanks again baltwo!
Here's how I did it:
1. I copied the whole Library/Preferences file of my corrupted user id to my new user id (in which I had confirmed everything worked. (To make sure it has something to do with the preference files.)
Result: Lightroom won't start in 64 bit mode.
2. I copied the clean preferences list back to my clean user profile (LR3 worked again in 64bit) and only copied the "dirty" Lightroom 3 plist files to my new userid preferences folder.
Result: Lightroom3 did not work anymore in 64 bit mode. So it had to be in de Lightroom preferences.
3. I started with my "dirty" LR3 preference file in 32 bit mode.
I started searching for errors.
First of course in the 3rd party plugins. I noticed that all my third party plugins were installed but not running. So removed all corrupted plugins and voila! It runs again in 64 bit mode.
So now I redownload the plugins and install them one by one.
Still running ok!
Probably something has corrupted my plugins directory, not sure what that could be. Except that I'm synchronizing a higher level directory including this one, so maybe that is it.
Thanks everyone for the help!

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