AS2 error The FILE send adapter cannot open file

I have AS2 setup under biztalk. I have receive port which listen to HTTP adapter and keep listening on web site.Then there is corresponding send port which just write that file in folder . Send port just have filter for Receive adapter name.
It works fine, but some time I get error message 
The FILE send adapter cannot open file <folder name\guid.txt > for writing.
 Details: The system cannot find the path specified.
I am not able to understand what is error for this? Please help me to figure-out this. 

Specifying the Backup transport is not going to solve the problem. Specifying the backup transport in this case is something like addressing the symptom of the issue and not finding the solution to root cause of the issue.
As you specified, if the mentioned error only happens some time but not always. In this case, the message "The
FILE send adapter cannot open file <folder name\guid.txt > for writing." would just be a warning message. Just by setting the retry in the send port will solve the issue. i..e Since this issue occurs rarely, it may be short lived glitch.
So by setting the retry count (lets say 3 times) with retry interval (let say 5 mins), this issue can be easily mitigated. You would not lose the message. So during the glitch you would get this message as warning, send port will retry "after specified
retry interval so after 5 mins", so by that time chances of files transfer is high. So this problem can be easily handled just by having retry count and retry interval in send port.
But you need to find the actual cause for this issue or you need to find the permanent resolution for this issue.
If this answers your question please mark it accordingly. If this post is helpful, please vote as helpful by clicking the upward arrow mark next to my reply.

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