Settings Randomly Change (i.e. SMTP Enable is now unselected)

Has anyone ever experienced this?
Basically, all is fine, things have been working for months, then suddenly something happens where a service doesn't restart properly.
You investigate and a setting is turned off.
This is the fourth time now this has happened, specifically to SMTP Enable option in Mail settings. (Obviously mail won't restart, until I go in manually and click that option to be enabled).
This morning it happened to me again during a mailbfr backup, the service was stopped, then never restarted. Just said "Mail server is down" over and over again. Looked and the "SMTP Enabled" option was unselected. Selected it, and all was well again.
I looked at the logs and nothing seemed really out of place except maybe the following ...
Apr 3 02:00:03 ns1 postfix/master[80787]: terminating on signal 15
Apr 3 02:00:03 ns1 postfix/postfix-script[32737]: fatal: the Postfix mail system is not running
Apr 3 02:00:09 ns1 postfix/master[32782]: daemon started -- version 2.4.3, configuration /etc/postfix
Apr 3 02:00:10 ns1 postfix/qmgr[32785]: F090416B8AF0: from=, size=4954, nrcpt=1 (queue active)
Apr 3 02:00:40 ns1 postfix/smtp[32788]: connect to returnmail49.fondgivewayutilities.com[208.88.53.76]: Operation timed out (port 25)
Apr 3 02:01:09 ns1 postfix/master[32782]: master exit time has arrived
Apr 3 02:01:09 ns1 postfix/master[32853]: daemon started -- version 2.4.3, configuration /etc/postfix
Apr 3 02:01:10 ns1 postfix/qmgr[32855]: F090416B8AF0: from=, size=4954, nrcpt=1 (queue active)
Apr 3 02:01:40 ns1 postfix/smtp[32857]: connect to returnmail49.fondgivewayutilities.com[208.88.53.76]: Operation timed out (port 25)
Apr 3 02:01:48 ns1 postfix/pickup[32854]: 43A3316BA18F: uid=0 from=<root>
Apr 3 02:01:48 ns1 postfix/cleanup[32880]: 43A3316BA18F: message-id=<[email protected]>
Apr 3 02:01:48 ns1 postfix/qmgr[32855]: 43A3316BA18F: from=<[email protected]>, size=3420, nrcpt=1 (queue active)
Apr 3 02:01:49 ns1 postfix/local[32884]: 43A3316BA18F: to=<[email protected]>, orig_to=<root>, relay=local, delay=107, delays=107/0.41/0/0.11, dsn=2.0.0, status=sent (delivered to file: /dev/null)
Apr 3 02:01:49 ns1 postfix/qmgr[32855]: 43A3316BA18F: removed
Apr 3 02:02:09 ns1 postfix/master[32853]: master exit time has arrived
Apr 3 04:07:50 ns1 postfix/postqueue[35499]: warning: Mail system is down -- accessing queue directly
Apr 3 04:09:00 ns1 postfix/postqueue[35537]: warning: Mail system is down -- accessing queue directly
Is this root email thing something from the server to itself or just coincidence or a hacker or what?
Anyways, I'm really curious if others have experienced settings just changing themselves on their own ever.
Feedback would be appreciated, thanks.
-Jessee

Yeah, I tried that, tough to know if it works though because it's really a problem that isn't reproducible. Just seems to happen once every few months.
I actually removed this file back when I had some DNS issues with Server Admin. I added a DNS entry, and when I clicked on save, all of my DNS entries disappeared. Suddenly, nothing worked. It deleted all of my DNS entries. Was very scary, but in the process of repairing my server I removed the plist file. So I've actually removed the file once prior.
Again, afterwards, all things seem normal, and stay normal; but then suddenly, a backup occurs or I change a setting in Server Admin and Server Admin modifies something it shouldn't be (or a setting is lost somewhere).
I figured at first it was a bug, so I've been waiting for these issues to ... well go away I guess (with the constant updating of my Server Tools from Apple with each OS X Server Update. But seems like these things are still occurring. Last time this happened for me was back on OS X Server 10.5.4. It's been good up until about a week ago.
Thank you for the advice though Pterobyte. Have you ever ran across this before yourself? Does Server Admin actually just get out of sync every once in a while? Not a big deal if it does I suppose, but it's a real shame to have to baby a server.
Client: Our mail server is down!
Me: Oh yeah, that's just Apple losing it's settings... :/
Message was edited by: Oranges2Apples

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